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The primary risks are that the medication will lose its potency and fail to work, or that the sterile environment inside the vial has been compromised, leading to a risk of infection

GLP-1 receptor agonists (semaglutide and tirzepatide compounds) help regulate appetite, blood sugar, and how full you feel

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Fortunately for most GLP-1 users, the gastrointestinal side effects are mild to moderate in severity, generally tolerable and tend to improve with time, especially with careful and slow dose titration

and Canadian federal health authorities as of mid-2025, the primary indication they are used for, and key differentiators between them: In Part 2 , we evaluate how to choose between GLP-1 molecules, using a goal-based approach