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In these trials, the medication was started at a very low dose, and the dosage was escalated gradually to maximize efficacy while minimizing early adverse effects, particularly gastrointestinal events that were consistent with Phase 2
Clinical trials showed 24.2% average weight loss at 48 weeks using the 12mg dose
Individual protocols must be personalized based on body composition, metabolic status, and physician assessment
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The least squares mean change compared to placebo is -10.7 with 4 mg retatrutide, -21.6 with 8 mg, and -18.7 with 12 mg
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