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It is plausible that GLP-1 agonists could decrease reward (i.e., pleasure) and cravings for addictive substances. Plausible, but not confirmed
It induces direct cardiomyocyte toxicity: adult rat ventricular myocytes exposed to 20100 M TMAO show a 2628% reduction in fractional shortening, a 3147% decrease in maximal shortening/relengthening rates, and a 1320% prolongation of calcium removal time (Savi et al., 2018)
The effects of GLP-1 receptor agonists on weight loss and glycemic control: A systematic review and meta-analysis
This hormone is naturally produced in the gut and helps regulate blood sugar levels by increasing insulin secretion, slowing gastric emptying, and signaling the brain to reduce appetite
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