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TRIUMPH-3: Obesity with Established Cardiovascular Disease (July 2026) TRIUMPH-3 enrolled 1,949 adults with severe obesity (BMI 35) and established cardiovascular disease, with or without type 2 diabetes, randomized 1:1:2 to retatrutide 9mg, 12mg, or placebo over 80 weeks
Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin Axis
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Brain function is especially vulnerable when mitochondrial energy becomes inconsistent
In response to growing concern surrounding delayed gastric emptying and aspiration risk, anesthesia societies and regulatory agencies have issued updated guidance addressing perioperative management of patients taking semaglutide and tirzepatide medications
Prunes remain one of the most effective natural remedies for constipation, with sorbitol providing an osmotic laxative effect alongside fiber
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