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p = 0.60) ( In terms of safety, gastrointestinal adverse effectsparticularly nauseawere common across both sexes, but women reported higher rates of intolerance, which may lead to treatment discontinuation ( The reduction in MACE with SGLT-2 inhibitors appears to be less consistent in women with type 2 diabetes than in men, while GLP-1 receptor agonists provide similar cardiovascular benefits across sexes

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This directly addresses the concern about semaglutide and muscle loss

For example, in the reaction with a hydroxide, we are comparing the leaving group ability of the hydroxide ion with the conjugate base of the amine: Comparing the p K a values of water (15.7 or 14 according to recent debates J