We are just now reaching the precipice where five- and 10-year follow-up data are becoming available for patients taking GLP-1 medications, said Muaaz Wajahahth, a fourth-year medical student at Michigan State University College of Human Medicine and primary investigator of, GLP Receptor Agonist Use is Associated with Increased Risk of Osteoporosis, Gout and Osteomalacia in Adults with Type 2 Diabetes and Obesity. Any medication that sees this rapid adoption warrants close examination, particularly in orthopaedics where obesity and surgical intervention often overlap, and when the long-term effects of GLP-1 RA exposure on bone and joint health remain poorly understood. At the same time, researchers are examining how GLP-1 use may affect recovery rates after orthopaedic surgery
The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3
Weve got this momentum behind us
Studies suggested that GLP-1 receptors are located in the human brainparticularly within the hypothalamus, underline a central mechanism contributing to their effects on glucose metabolism and weight loss (14, 15)
The choice of medication should be guided by NICE recommendations for individualised diabetes care (NG28), considering factors such as HbA1c targets, cardiovascular risk, renal function, patient preferences, and the specific anatomical changes from surgery