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The problem is usually insufficient deep sleep, specifically stage 3 slow-wave sleep, where the most critical restoration occurs

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Results The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue

This is similar to the formation of cystine from two cysteines as diagrammed in the Cystinuria page

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