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Many clinicians will want objective follow-up testing before changing PAP therapy or declaring remission

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Real world implementation requires clinician supervision, defined objectives, and monitoring

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It has small older human studies suggesting possible sleep effects, but the evidence is limited, outdated, and not strong enough to place it in the same category as melatonin

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Little SA, Speight J, Leelarathna L et al (2018) Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: two-year follow-up in the HypoCOMPaSS randomized clinical trial

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