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that nomination was withdrawn and ipamorelin was removed from Category 2 effective September 2024

For hyperpigmentation disorders, tretinoin may prevent the transcription of the enzyme tyrosinase which minimizes melanogenesis

Sci Transl Med 2020;12:eaay8071

From experimental data of kinetic measurements of BRET, following vehicle and baseline corrections, quantification of induced responses from individual peptide concentrations was determined by calculating the net area under curve from the 10 min response (AUC 0-10min) ) in GraphPad Prism version 9.0.1 (GraphPad Software Inc., San Diego, CA)

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