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GLP-1s are effective at weight management due to their appetite reducing effects

Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window

Heres just how powerful this effect is: 37% of a solid meal remained in the stomach four hours after eating (compared to 0% in the placebo group!) in patients who had been on semaglutide for 12 weeks

Furthermore, the option to continue or initiate new AD medication during the trial, including the amyloid lowering monoclonal antibodies, was not a randomization stratification factor and may therefore act as a confounding factor if their use across treatment arms is unequal

Tirzepatide followed as Mounjaro and Zepbound, engaging an additional gut hormone receptor and producing larger average reductions in published trials