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doi: 10.1042/BSR20193160 292 LiGTanWFangYWuXZhouWZhangCet al
The key difference is one of class: Cagrilintide is an amylin analog (a separate satiety pathway), not an incretin agonist which is why it is often combined with GLP-1 rather than compared as an alternative
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In the REDEFINE 1 study the combination produced 20.4% weight reduction, versus 11.5% for cagrilintide alone and 14.9% for semaglutide alone
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