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Bioinformatics 30 , 13631369, (2014)

If you have a known copper allergy (sometimes identified through reactions to copper jewelry), patch test any GHK-Cu product on your inner forearm for 48 hours before applying it to your face

The most commonly used formulation is Trimix a compounded medication containing three active ingredients: papaverine, phentolamine, and prostaglandin E1 (alprostadil)

Patients with a history of cancer, or those with elevated cancer risk, should approach peptide therapy with particular caution and only under close medical supervision