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In recent years, the food and pharmaceutical industries have increasingly favored the use of natural products over synthetic compounds, based on the assumption that synthetic agents are inherently more toxic

Zhang T, Ma M, Chen T, Zhang L, Fan L, Zhang W, Wei B, Zhang D, Li S, Xuan W, Noctor G, Han Y (2020) Glutathione-dependent denitrosation of GSNOR1 promotes oxidative signalling downstream of H 2 O 2

Phase C: The body may begin to lose its ability to maintain internal equilibrium

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These findings highlight the need for standardized protocols to assess the complexity of ibuprofen and microplastics effects on reproduction accurately (de Ruijter et al., 2020)