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In mutant SOD1, these aberrant disulfide bonds involve cysteine residues Cys 6 and Cys111, and in both mutant and WT TDP-43, cysteines Cys173, 175, 198, and 244 in the RNA-recognition motif (RRM) are involved (Cohen et al., 2012

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19 , e1010387 (2023)

GLP-1 Treatment Alone GLP-1 treatment works mainly through the GLP-1 pathway

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