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Science 296 : 678682
2020;180(3):585600 e19
Neuregulin and IGF1 can act synergistically to increase mitochondrial biogenesis and mtDNA replication in primary Schwann cells, which requires both the ERK and PI3K signaling pathways (Ribeiro et al., 2014)
The mechanistic logic NNMT inhibition preserving NAD+ salvage, increasing adipocyte energy expenditure, and protecting against diet-induced adipose accumulation in animal models places 5-Amino-1MQ in a distinct niche compared to the metabolic peptides that dominate the rest of the obesity-research landscape
Several factors likely contribute to variable results
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