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The K151R mutant exhibited significantly increased Rheb ubiquitination, while the K151Q mutant, which mimics the acetylated form of Rheb, did not increase Rheb ubiquitination (Fig

thus, appropriate tests need to be carried out to rule out this condition if suspected.[16] Therapeutic response to cyanocobalamin may decrease due to elderly age, infection, renal insufficiency, diabetes mellitus, marrow suppressants use (e.g