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tb is mainly driven by Th1 cells that secrete IFN- , IL-2, and TNF-

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While the changes in lipid parameters are smaller compared to those elicited by LY2405319 or PF-05231023, pegbelfermin is the first FGF21 analog to demonstrate beneficial hepatic effects in NASH patients, with daily administration yielding approximately a 30% relative reduction in liver fat content

Toll-like receptor-4 inhibitor: Although prior clinical trials with IL-1 and TNF- have failed to show benefit in patients with SAH, a new trial involving a TLR-4 inhibitor is underway