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On the other hand, hepatocytes were transfected with p53 siRNA, progerin siRNA, p21 siRNA, or nontarget siRNA (called NC), and then administered with H 2 O 2 (200 nM) for 24 h

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2011 Apr 30;377(9776):1494

The mechanisms underlying these regulatory networks fundamentally revolve around two major axes: the availability of methyl donors and the direct interference with epigenetic enzyme activity