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The ROS generation was detected with a Leica fluorescence microscope (Leica DM6000B) using Leica LAS X software, and quantitative analysis was performed with ImageJ software (version 1.60

It also helps to correct severe deficiencies very quickly (if the deficiency is not based on genetic abnormalities which may require a specific form(s) of B12)

The panel agreed that initial treatment should be parenteral for severe cases, while high-dose oral B12 can be considered for maintenance

Comparison of the chemical properties of selenocysteine and selenocystine with their sulfur analogs

We hope this has cleared up the confusion and provided a clear path forward