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If the atoms holding the nonbonded pair are more electronegative, they will be less likely to share electrons, and that molecule will be a poorer nucleophile (nu:) and weaker base
Hashash JG, Thompson CC, Wang AY
KoganIRamjeesinghMLiCKiddJFWangYLeslieEMet alCFTR directly mediates nucleotide-regulated glutathione flux
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