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First, the biodistribution of the liposomal formulation was not directly assessed, limiting the ability to correlate regional biochemical effects with drug delivery efficiency

Use a larger syringe (e.g., switch from 30-unit to 100-unit) Reduce reconstitution volume for higher concentration Split dose into multiple injections Dose is less than 2 units

Sulfur is needed in phase 2 detoxification reactions

DSIP/Emideltide was placed on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks in September 2023

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