Most of phase 2 reactions take place in cytosol and involve conjugation with endogenous compounds via transferase enzymes
These essential nutrients may perform many critical roles in the body for supporting the neurological system, mitochondrial health, and energy metabolism
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Based on the sum of cited evidence it appears reasonable to suggest initiation of glutamate oxidation by transamination as the default pathway, but participation of GDH may occur in situations when an insufficient match between glutamate biosynthesis and degradation is not possible because of different rates, too long distances between biosynthesis and degradation sites, or prevailing conditions in vitro
Gpx4 protects mitochondrial ATP generation against oxidative damage