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Upregulation of IGF-IR is detected in ovarian cancer cell that acquire resistance to the p110 isoform-selective inhibitor taselisib and in PI3K- inhibitor idelalisib-resistant chronic lymphocytic leukemia [125, 127]
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The Yale team confirmed that Cyp2e1 was reduced independently of whether the animals were consuming alcohol suggesting it's a direct drug effect, not secondary to reduced intake
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