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The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4
Moreover, additional roles for GLP-1 have been revealed since the discovery of an extrapancreatic distribution of GLP-1 receptors in multiple organs such as the gastrointestinal tract, lung, heart, liver, and kidneys [58910], and evidence shows that administration of GLP-1 or GLP-1 RAs result in beneficial effects in these organs, indeed [11]
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