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Kienesberger K, Pordes AG, Vlk TG, Hofbauer R
In 2009, the first compound demonstrating anti-obesity effects was reported, a dual agonist targeting both the GLP-1 receptor and the glucagon receptor [24]
Then the translocation of mycotoxins and microbial products (e.g., LPS) to the liver via the portal vein triggers hepatic inflammation, oxidative stress, and Nrf2-mediated detoxification responses