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Weekly Schedule Example Option A (standard): 1 mL once weekly 10 doses (10 weeks) Option B (enhanced): 1 mL twice weekly 10 doses (5 weeks) Option C (light): 0.5 mL once weekly 20 doses (20 weeks) 4

Mt Sinai J Med 55: 1120

FIGURE 4 Development of Ketosteroid Isomerase Activity in the Glutathione Transferase Structure The discovery of human GST A3-3 (HsaGST A3-3) and its association with steroidogenic tissues (Johansson and Mannervik, 2001) prompted the search for mammalian orthologs with similar outstanding catalytic efficiency

Like peptides, they are not approved for human use and are seen as experimental drugs with a risk of serious liver damage, thrombosis and heart problems

IGF-1 and insulin share similar signaling pathways, particularly the PI3K and AKT pathways