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GLP's effects appear agnostic to SUD diagnosis or substance
Black people appeared to lose less weight than White people, but the difference was not statistically significant after adjusting for other factors
Typically, GLP-1 secretion in response to oral glucose is more pronounced than that in response to other administration routes 37 , suggesting a significant opportunity for future investigations to directly examine the analgesic effects of oral glucose through its impact on GLP-1 levels
The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]
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