Yes, glutathione can help lighten dark spots but the effect is gradual, and the results depend on several factors: Cause of pigmentation (acne, melasma, sun damage, post-inflammatory hyperpigmentation) Skin tone and type Duration of use Method of administration Combination with other treatments For example, in cases of melasma or stubborn acne marks, glutathione is most effective when used alongside other therapies such as chemical peels, lasers, and prescription creams
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A double-blind, randomized, placebo-controlled trial demonstrated that perioperative high-dose intravenous injection of Gln (0.5 g/kg/day, P.O for 3 days) raised plasma Gln concentrations and maintained plasma GSH levels in postoperative patients undergoing cardiopulmonary bypass (CPB) [113]
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So, if youre taking a liquid liposomal glutathione, try to allow some of if to sit in your mouth for 30 seconds or so before swallowing