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Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)
Answer: Most reported side effects are mild and dose-related, including injection-site reactions, transient water retention, and occasional numbness or tingling
Regular administration of these injections can support overall health by reducing the frequency and severity of illnesses
Once stable, annual monitoring is usually sufficient
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