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Monitoring caloric intake becomes as important as monitoring the dose itself
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[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance
Transdermal delivery systems may additionally cause local skin reactions , including redness, itching, or irritation at the application site
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