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Adults who have difficulty absorbing B12 through oral supplements or diet, including those with digestive issues or dietary restrictions

Grober JS, Yershov AL, et al

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Coskun and Urva (2022, pharmacological description) describe the engineering: modified sequence derived from native GIP, Aib2 and Aib13 substitutions resisting DPP-4, and a C20 diacid fatty-acyl chain grafted to a lysine via a gamma-glutamate linker to extend half-life to approximately 6 days