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Why researchers care Fat-cell shrinkage and higher NAD+ without appetite suppression

The American Heart Association defines metabolic syndrome by the presence of three or more of the following risk factors: abdominal obesity, high blood pressure, elevated fasting glucose, high triglycerides, and low HDL cholesterol

Although SGLT2 inhibitors are proven to block the SREBP1c - ACC axis in metabolic tissues of animal models, we still need further proof to know if they directly affect tubular ferroptosis by regulating DNL in DKD (Kim et al., 2019)