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Since MTHFR controls the detoxification of homocysteine and the supply of methyl groups for SAM synthesis, a reduction in its activity can affect homocysteine metabolism and disturb cellular methylation processes
Other markers like phosphatase and tensin homolog (PTEN), engrailed 2 (EN2), fatty acid synthase (FAS), interleukin-6 (IL-6), transforming growth factor 1 (TGF- 1), Transmembrane serine protease 2 (TMPRSS2-ERG), Zinc finger E-box binding homeobox 1(ZEB1), Snail family transcriptional repressor 1 (SNAI1), Androgen receptor splice variant 7 (AR-V7), Annexin A3 (ANXA3), A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1), and Proliferating cell nuclear antigen (PCNA) are also used for PCa detection (Fig
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doi: 10.1083/jcb.202207022
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