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Ongoing trials, such as the T-Plaque trial 17 (evaluating tirzepatide) and the STRIDE trial 18 (evaluating semaglutide), aim to provide further insights into the cardiovascular benefits of GLP-1RAs

Until that qualification work is done, the imaging and fluid measures are instruments for understanding the mechanism and selecting patients, while the question of whether these drugs modify the disease still belongs to the clinical endpoints

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