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Following the 15-day METH treatment period, the QR treatment groups were intragastrically administered with QR (100 mg/kg or 200 mg/kg, suspended in 0.5% (w/v) CMC - Na) for 21 days

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A study in The Journal of Clinical Investigation demonstrated that glucagon infusion increases energy expenditure by 100 to 200 calories per day (4), and retatrutide replicates this effect through sustained receptor activation