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The most commonly reported adverse effects in the Phase 2 trial included: Nausea the most prevalent side effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can be uncomfortable) Eructation (belching) Injection-site reactions (such as redness, bruising, or discomfort at the injection site) These effects are typically mild to moderate in severity and tend to be most pronounced during the first few weeks of treatment or following each dose increase

If recovery is adequate, volume can increase toward 16 to 20 weekly sets during the intensification phase

Be careful with heavy alcohol or high-dose stimulants because they disturb sleep and appetite cues

These sections were immediately placed in primary fixative solution (2% formaldehyde, 2.5% glutaraldehyde, and 2 mM CaCl 2 in 0.15 M cacodylate buffer), 1 mm 3 pieces were then transferred into a new fixative solution for 3 h at room temperature, washed three times with 0.15 M cacodylate buffer and then post-fixed and contrasted using a modified OTO protocol (2% osmium tetroxide + 1.5% potassium ferricyanide-(II), thiocarbohydrazide, 2% osmium tetroxide, 2% uranyl acetate) 74