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The native peptide 1 had an IPGTT curve similar to the vehicle as expected from previous studies
Nevertheless, further investigations are warranted to elucidate the specific phosphorylating sites within Sec24C modified by VRK2
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These residues, under oxidative stress, are prone to oxidation in sulfenic acid, which efficiently reacts with GSH leading to a glutathionylated-cysteine derivative (GSSR)
Since its 2017 approval as a diabetes treatment, semaglutide (the generic name for Ozempic and its offshoots, Rybelsus and Wegovy) has become one of the most popular prescription drugs in the U.S
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