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Patients might describe generalized pruritus, widespread areas of tenderness or hyperesthesia, or skin reactivity in areas distant from injection sites

Alternatives range from similar injectable medications to pills and healthy lifestyle changes

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Secondly, we employed genetic instruments to proxy trait/drug exposure, which may help reduce confounding bias and prevent reverse causation

First-generation antihistamines are not directly harmful to blood pressure, but their sedating effects and potential interactions with other medicines make them less suitable for routine use in people managing complex health conditions