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There are some concerns around use of the GLP-1 agents, such as weight regain after stopping treatment, the potential for a loss of skeletal muscle mass, long-term adherence, and the limited evidence that exists for long-term safety, Moiz et al say

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In our study, liraglutide prevented the TGF-1 + IL-1-induced augmentation of mitochondrial respiration in fibroblasts, indicating that activating GLP-1R could maintain mitochondrial homeostasis under inflammatory stress