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The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies

PMCID: PMC6328175

When combined, patients may experience: Excessive appetite suppression , leading to inadequate caloric intake Unintended weight loss beyond therapeutic targets Nutritional deficiencies if dietary intake becomes severely restricted Difficulty maintaining energy for daily activities Hypoglycemia risk in patients also taking insulin or sulfonylureas, due to reduced food intake Gastrointestinal effects may also be compounded

The absence of interaction evidence across three independent pathways (CYP2C9, OATP1B1/1B3, BCRP) makes a pharmacokinetic interaction between these two compounds improbable

doi: 10.12688/f1000research.7634.1 146 CaraciFSpampinatoSFMorgeseMGTasceddaFSalluzzoMGGiambirtoneMCet al