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In a neurotrophic activity assay, Dihexa was found to be 7 orders of magnitude more potent than BDNF
When semaglutide cuts your daily food intake by a third or more, four things happen to B vitamin status that may justify adding B12 to the protocol: Less dietary B12 coming in
Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss
But if you're dragging despite sleep, dealing with unexplained weight resistance, or you've tested low for B12, it's worth the conversation
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