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The GLP-1 therapy, already widely used globally, offers blood-sugar control along with clinically proven weight-loss benefits and protection against heart and kidney complications

Any drug or supplement that competes for those same enzymes can slow isotretinoin's breakdown, pushing blood levels higher than intended

They can be solid or fluid-filled, and while typically benign, larger nodules can cause swallowing or breathing issues

Individuals with severe GI conditions Gastroparesis, severe inflammatory bowel disease, and other conditions affecting GI motility could be worsened by a compound that further slows gastric emptying

doi:10.1016/S0140-6736(19)31271-1 Rodbard HW, Rosenstock J, Canani LH, et al