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The interactions between GLP-1RAs and other drugs may affect drug efficacy or increase the risk of adverse reactions, as well as the dose adjustment of the combination of hypoglycemic drugs, which put forward higher requirements for clinicians

doi: 10.1007/s00125-016-3929-0 79 ChenHJLeeYJHuangCCYenYCLinYF

Prucalopride (Motegrity) is a 5-HT4 agonist that stimulates colonic motility through a non-GLP-1 pathway

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Receptor downregulation after 810 weeks of continuous use necessitates cycling protocols (8 weeks on, 4 weeks off) to maintain response magnitude