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Shami et al., 2003] were selectively activated by GST M1 and GST A1, respectively, and produced abundant NO in the tumor and contributed to chemotherapy by GSH consumption, DNA synthesis inhibition and inhibition of enzymes responsible for cellular damage repair ( Figure 2E )

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44 The most prevalent application of classical machine learning in healthcare is precision medicine, which forecasts the treatment procedures most likely to be effective for a patient by considering various patient characteristics and the context of the therapy (Kharb and Joshi)

Future therapies for prevention of disc degeneration, targeted disc regeneration and biological modification of the degenerative cascade might prevent or reverse pathological changes across all spinal regions