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Stefanou MI, Theodorou A, Malhotra K, et al
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That said, "works the same" does not mean "feels the same" or "is equally convenient." Each site has distinct practical advantages and drawbacks that matter in everyday use
Indeed, acute elevated peripheral insulin levels may increase insulin in cerebrospinal fluid, whereas, chronic peripheral hyperinsulinemia (such as insulin resistance or T2DM) may downregulate insulin receptors of the BBB, impair brain insulin uptake, and ultimately lead to learning, memory, and cognitive deficits (14, 52)
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