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No changes in cancer markers, hormones, liver, or kidney function reported (only monitored in the short term days)

Clinical trial data demonstrating average weight loss of 15-22% of baseline body weight has shifted patient and provider perceptions about what's possible with medication

Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

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