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H 2 S, as an endogenous gaseous signaling molecule, participates in life activities such as cell survival, proliferation, differentiation, migration, and death by regulating energy metabolism, inflammatory response, and oxidative homeostatic balance, and plays an important biological effect in physiological and pathophysiological regulation of multiple systems in the body

Also levels of cleaved PARP (PolyADP ribose polymerase) 42 were detected with the appearance of a 90 kDa lower band as opposed to 113 kDa uncleaved PARP in GNE knockdown cells indicative of DNA damage (Fig