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The Cox model was additionally adjusted for diabetes and obesity because these factors remained imbalanced after weighting
In addition, GLP-1RA can also indirectly affect RAAS by reducing the circulating level and action of renin and AngII, playing a role in sodium excretion and diuresis by regulating the ion exchange of potassium, chlorine and calcium in renal tubules (178)
Across all these drugs, the common mechanism of action are glucose lowering via -cell GLP-1R, slowed gastric emptying (gut) and appetite suppression via central effects (McLean et al., 2021)
If tolerated and under the supervision of your prescriber, your dose may be increased to 5mg weekly then after a further four weeks, it may be increased by another 2.5mg up to a maximum dose of 15 mg once weekly
These findings remain preliminary and should be interpreted cautiously, but they highlight the peptides complex regulatory effects on cellular biology
