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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

Safety Considerations and Who Should Seek Provider Guidance NAD precursors (NMN, NR) are generally well-tolerated at standard doses, though some users report mild nausea or headache

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