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It's also common to lose some muscle mass along with fat while on these drugs, which can be problematic, Kessler writes

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Clinical studies indicate that some patients may experience weight loss as early as two weeks after starting Zepbound, though the most significant and sustained results typically become noticeable after four to eight weeks

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A particularly concerning condition associated with these drugs is stomach paralysis, or gastroparesis, a chronic condition where the stomach takes longer to empty its contents and potentially leads to blockages, resulting in significant discomfort and potentially severe complications